Heavy Metals and Gene Expression

Heavy Metals and Gene Expression

Heavy Metals and Gene Expression

Expression of Genes in Relation to Cadmium, Mercury and Lead

Monastero RN1,2Vacchi-Suzzi C3,4Marsit C5Demple B6,7Meliker JR8,9.

Abstract

Heavy Metals and Gene Expression is an interesting and unique study. There is growing evidence of immunotoxicity related to exposure to toxic trace metals, and an examination of gene expression patterns in peripheral blood samples may provide insights into the potential development of these outcomes.

This pilot study aimed to correlate the blood levels of three heavy metals (mercury, cadmium, and lead) with differences in gene expression in 24 participants from the Long Island Study of Seafood Consumption.

We measured the peripheral blood mRNA expression of 98 genes that are implicated in stress, toxicity, inflammation, and autoimmunity.

We fit multiple linear regression models with multiple testing correction to correlate exposure biomarkers with mRNA abundance.

The mean blood Hg in this cohort was 16.1 µg/L, which was nearly three times the Environmental Protection Agency (EPA) reference dose (5.8 µg/L).

The levels of the other metals were consistent with those in the general population: the mean Pb was 26.8 µg/L, and the mean Cd was 0.43 µg/L.

The expression of three genes was associated with mercury, four were associated with cadmium, and five were associated with lead, although none were significant after multiple testing correction.

Little evidence was found to associate metal exposure with mRNA abundance for the tested genes that were associated with stress, toxicity, inflammation, or autoimmunity. Future work should provide a more complete picture of physiological reactions to heavy metal exposure.

KEYWORDS:

Cd; Fish; Hg; Pb; mRNA

PMID:29986418

DOI: 10.3390/toxics6030035

Toxics. 2018 Jul 6;6(3). pii: E35.

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Dr. George J. Georgiou, Ph.D., N.D., D.Sc (AM), M.Sc., B.Sc, is a world-renowned expert in the field of holistic medicine and detoxification. As the inventor of the highly acclaimed Dr. Georgiou's Heavy Metal Detox Protocol, and the main product, HMD™ (Heavy Metal Detox), he has revolutionized the approach to natural heavy metal detoxification. With over 35 years of experience in natural medicine, he has authored 23 books, including the comprehensive guide 'Curing the Incurable with Holistic Medicine,' which offers invaluable insights and over 700 scientific references. Dr. Georgiou's groundbreaking work is sought after by individuals and practitioners worldwide through his Da Vinci Institute of Holistic Medicine and Da Vinci Holistic Health Center based in Larnaca, Cyprus.
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